January 2014, Parsippany, NJ, USA – Diagnostica Stago, Inc. introduces Megamix-Plus SSC (cat # 01078) and Megamix-Plus FSC (cat # 01077), for detection of procoagulant microparticles on both side-scatter and forward-scatter flow cytometers. Microparticles are tissue factor-bearing phospholipid vesicles that are a source of procoagulant phospholipids. Microparticle levels have been studied in several pathologies including cancer, diabetes, sickle cell disorder, and parasitic and viral infections.
Megamix-Plus FSC contains 0.5 and 0.9 μm beads with the addition of 0.1 and 0.3 μm beads for better discrimination of smaller sized particles. Megamix-Plus FSC is optimized to newer generation forward scatter (FSC) - instruments, such as Beckman Coulter’s Gallios® and Navios®.
Megamix-Plus SSC contains 0.5 and 0.9 μm beads with the addition of 0.16 and 0.2 μm beads. Megamix-Plus SSC is optimized to Becton-Dickinson’s side scatter (SSC) flow cytometers.
When used to calibrate a flow cytometer, Megamix-Plus SSC and Megamix-Plus FSC are powerful tools allowing subset differentiation and vesicle size measurement, providing MP gate analysis from 0.3 to 1.0 µm MP-equivalents. When paired with cell-specific antigen analysis, determination of the microparticle’s cell of origin is possible.
Megamix-Plus SSC and Megamix-Plus FSC join the existing line of functional microparticle assays from Stago. STA® Procoag PPL (cat # 00429) is a bar-coded clotting assay adapted to the STA line of automated coagulation analyzers to facilitate measurement of microparticle function in high-volume clinical studies. In addition, the MP reagent (cat # 86222), is designed to assess the effect of tissue factor present on the surface of circulating microparticles on thrombin generation using the Calibrated Automated Thrombogram® instrument (cat # 86186).
All procoagulant microparticle detection products are labeled for research use only (not for use in diagnostic procedures) worldwide.
Stago Canada Ltd is the exclusive provider of the Diagnostica Stago Hemostasis product lines in Canada and offers a complete system of coagulation instruments and optimized reagent kits for routine as well as specialty analysis. Stago Canada Ltd is the Canadian subsidiary of Diagnostica Stago, S.A.S. France, a leader in the development and manufacture of Hemostasis products. For more information about any Stago product or service, please call 416-774-2478 or visit our website at http://webca.stago.com.
GALLIOS and NAVIOS are registered trademarks of Beckman Coulter, Inc.
Susan Taylor, Director of Marketing
Diagnostica Stago, Inc.